Afficher la couverture 'Size and Flexibility Define the Inhibition of the H3N2 Influenza Endonuclease Enzyme by Calix[n]arenes | Tauran, Yannick' en grand format
/5

0 avis

Size and Flexibility Define the Inhibition of the H3N2 Influenza Endonuclease Enzyme by Calix[n]arenes

Archive ouverte : Article de revue

Tauran, Yannick | Cerón-Carrasco, José Pedro | Rhimi, Moez | Perret, Florent | Kim, Beomjoon | Collard, Dominique | Coleman, Anthony | Pérez-Sánchez, Horacio

Edité par HAL CCSD ; MDPI

International audience. Inhibition of H3N2 influenza PA endonuclease activity by a panel of anionic calix[n]arenes and β-cyclodextrin sulfate has been studied. The joint experimental and theoretical results reveal that the larger, more flexible and highly water-soluble sulfonato-calix[n]arenes have high inhibitory activity, with para-sulfonato-calix[8]arene, SC8, having an IC50 value of 6.4 μM. Molecular docking calculations show the SC8 can interact at both the polyanion binding site and also the catalytic site of H3N2 influenza PA endonuclease

Consulter en ligne

Suggestions

Du même auteur

Chimie médicale : cours et QCM / Jean Farjanel,... Florent Perret,... Jacqu...

Livre | Farjanel, Jean (19..-....). Auteur | 2012 - [Nouvelle édition revue et augmentée]

Optimization of surface treatment on MEMS probes for single-cell capture an...

Archive ouverte: Article de revue

Hayashi, Kensaku | 2019

International audience. Micro-electromechanical systems (MEMS) tweezers developed for the trapping and characterization of bio molecules such as DNA are also capable of cell handling, which will enable further appli...

Multiple Selection Criteria for Probiotic Strains with High Potential for O...

Archive ouverte: Article de revue

Alard, Jeanne | 2021-03

International audience. Since alterations of the gut microbiota have been shown to play a major role in obesity, probiotics have attracted attention. Our aim was to identify probiotic candidates for the management o...

Du même sujet

Proteolytic activity of Lactobacillus strains isolated from Mongolian tradi...

Archive ouverte: Article de revue

Raveschot, Cyril | 2020-01-30

Le Réseau Mixte Technologique Sols et Territoires : développer la connaissa...

Archive ouverte: Article de revue

Guellier, Camille | 2014

absent

Soil bioindicators: how soil properties influence their responses and to se...

Archive ouverte: Communication dans un congrès

Pauget, Benjamin | 2015-05-03

International audience

Les incitations financières à la réalisation d’objectifs comportementaux li...

Archive ouverte: Article de revue

Crainich, David | 2022-02

International audience. Les programmes octroyant des récompenses pécuniaires aux individus qui parviennent à atteindre un objectif lié à la santé (arrêter de fumer, perdre du poids, etc.) ont pour but de favoriser l...

Transcriptome assembly and abiotic related gene expression analysis of date...

Archive ouverte: Article de revue

Rekik, Imen | 2019-11-30

Characterization of free exopolysaccharides secreted by Mycoplasma myco...

Archive ouverte: Article de revue

Bertin, Clothilde | 2013

International audience. Contagious bovine pleuropneumonia is a severe respiratory disease of cattle that is caused by a bacterium of the Mycoplasma genus, namely Mycoplasma mycoides subsp. mycoides (Mmm). In the abs...

Chargement des enrichissements...