Effectiveness and safety of dupilumab for the treatment of atopic dermatitis in a real-life French multicenter adult cohort

Archive ouverte : Article de revue

Faiz, Sarah | Giovannelli, Jonathan | Podevin, Céline | Jachiet, Marie | Bouaziz, Jean-David | Reguiai, Ziad | Nosbaum, Audrey | Lasek, Audrey | Ferrier Le Bouedec, Marie-Christine | Du Thanh, Aurélie | Raison-Peyron, Nadia | Tetart, Florence | Duval-Modeste, Anne-Benedicte | Misery, Laurent | Aubin, François | Dompmartin, Anne | Morice, Cécile | Droitcourt, Catherine | Soria, Angele | Arnault, Jean-Philippe | Delaunay, Juliette | Mahé, Emmanuel | Richard, Marie-Aleth | Schoeffler, Amélie | Lacour, Jean-Philippe | Begon, Edouard | Walter-Lepage, Amélie | Dillies, Anne-Sophie | Rappelle-Duruy, Sandrine | Barete, Stéphane | Bellon, Nathalia | Beneton, Nathalie | Valois, Aude | Barbarot, Sébastien | Sénéchal, Julien | Staumont-Sallé, Delphine

Edité par HAL CCSD ; Elsevier

International audience. BackgroundDupilumab is the first biologic available to treat atopic dermatitis (AD). Its effectiveness and safety were demonstrated in clinical trials.ObjectiveWe sought to assess the effectiveness and safety of dupilumab in adults with AD in a real-life French multicenter retrospective cohort.MethodsWe included patients treated during March 2017-April 2018. Efficacy outcomes, including Scoring Atopic Dermatitis (SCORAD) and Eczema Area and Severity Index (EASI) scores, were collected at baseline and 3 months when available. Adverse events (AEs) were recorded at follow-up.ResultsWe included 241 patients. The median ± interquartile range (IQR) follow-up time was 3.8 ± 3.7 months. A ≥75% improvement in SCORAD was achieved in 27 of 163 (16.6%) patients, and a ≥75% improvement in EASI was achieved in 40 of 82 (48.8%) patients. The median SCORAD and EASI scores at 3 months were significantly lower than those at baseline (SCORAD ± IQR, 25 ± 21 vs 56 ± 27.4, P < 10−9 and EASI ± IQR, 4.1 ± 6.8 vs 17.9 ± 15.4, P < 10−9, respectively). Conjunctivitis was reported in 84 of 241 (38.2%) patients. The proportion with eosinophilia (>500 cells/mm3) during follow-up (57%) was higher than that at baseline (33.7%) (n = 172, P < 10−6). Dupilumab was stopped in 42 cases; 27 patients stopped because of AEs.LimitationsNo control group, missing data.ConclusionThis real-life study demonstrated a similar dupilumab effectiveness as that seen in clinical trials, but it also revealed a higher frequency of conjunctivitis and eosinophilia.

• Contient
• Sujet
• Description
• Oeuvre