Evaluation of emotional disorders before and during treatment with interferon beta in patients with multiple sclerosis

Archive ouverte : Article de revue

Ouallet, Jean-Christophe | Radat, Françoise | Créange, Alain | Abdellaoui, Mohamed | Heinzlef, Olivier | Giannesini, Claire | Hautecoeur, Patrick | Lamargue Hamel, Delphine | Deloire, Mathilde, | Brochet, Bruno | Jean Deleglise, Anne-Sophie | Lehert, Philippe

Edité par HAL CCSD ; Elsevier

International audience. Background: Domains encompassing emotional disorders in relapsing-remitting MS (RRMS) patients are still unclear.Methods: We performed a 24-month, multicenter, single-arm, prospective study. RRMS patients started IFN-β treatment at baseline. The primary endpoint was lack of emotional control, measured using the "Echelle d'HumeurDépressive" (EHD) scale three times at baseline and at 10 post-treatment visits. Secondary endpoints were emotional blunting, irritability, fatigue, depression and anxiety. A linear mixed covariance model assessed change from baseline on an intention-to-treat basis, under the assumption of no mood disorder effect (one-sided 97.5% level), in which autoregressive type of autocorrelation was tested.Results: Out of 79 recruited patients, 70 were analyzed: 80% female; mean (SD) age, 37.0 (11.5) years. Mean (SD) lack of emotional control score at baseline and Month 24 was 12.7 (4.4) and 12.6 (5.5), respectively, versus 10.1 (3.2) in a healthy control population matched for age and sex. Stepwise analysis identified younger age, male sex and antidepressant use as significant predictors of higher lack of emotional control values.Conclusions: Based on 24 months of prospective follow-up, the results of this study highlights a broad spectrum of emotional disorders in the MS population at the time of disease modifying drugs initiation but no major IFN-β-related emotional disorders (mood dyscontrol, anxiety, depression) were observed. However, sporadic occurrences of severe mood disorders and suicidality cannot be excluded.

Consulter en ligne

Suggestions

Du même auteur

Treating asymptomatic bacteriuria before immunosuppressive therapy during m...

Archive ouverte: Article de revue

Rouzaud, Claire | 2017-11

International audience

CD62L test at 2 years of natalizumab predicts progressive multifocal leukoe...

Archive ouverte: Article de revue

Pignolet, Béatrice | 2016-12-06

International audience

Cholecalciferol in relapsing-remitting MS: A randomized clinical trial (CHO...

Archive ouverte: Article de revue

Camu, William | 2019-06-26

International audience. OBJECTIVE:To evaluate the safety and efficacy of cholecalciferol in patients with relapsing-remitting MS (RRMS).METHODS:In this double-blind, placebo-controlled parallel-group, 2-year study, ...

Du même sujet

The geopolitics of emotion : how cultures of fear, humiliation and hope are...

Livre | Moïsi, Dominique (1946-....). Auteur | 2016

How to know a person : the art of seeing others deeply and being deeply see...

Livre | Brooks, David (1961-)

A practical, heartfelt guide to the art of truly knowing another person in order to foster deeper connections at home, at work, and throughout our lives-from the #1 New York Times bestselling author of The Road to Character and Th...

Emotional information processing in first and recurrent major depressive ep...

Archive ouverte: Article de revue

Nandrino, Jean-Louis | 2004-09-01

International audience. Depressive states are classically associated to increased sensitivity to negative events. However this hypersensitivity may not be stable in time, being absent in remission periods or further...

MSCopilot: New smartphone-based digital biomarkers correlate with Expanded ...

Archive ouverte: Article de revue

Tanoh, Ian-Christopher | 2021-10

International audience. Background: A previous clinical study showed the high specificity, sensitivity and reliability of MSCopilot, a software medical device designed by Ad Scientiam for the self-assessment of peop...

Ankle dysfunction in multiple sclerosis and the effects on walking

Archive ouverte: Article de revue

Massot, Caroline | 2021-08-14

International audience. Purpose: Even in the early stage of the disease, for patients suffering from multiple sclerosis (MS), the most common and reported biomechanical alterations in the lower limb are located at t...

Low back pain in patients with multiple sclerosis: A systematic review and ...

Archive ouverte: Article de revue

Massot, Caroline | 2021-04

International audience. PurposeThe prevalence and management of back pain in MS patients was assessed by a systematic review, and the results of a survey on the characteristics of low back pain in a sample of French...

Chargement des enrichissements...